Glucosamine acts as a "cushion" in the body around the periarticular portion. Gold shell high-density chitosan indicates that some patients with osteoarthritis have thinner and stiffer "spacers". Taking glucosamine as a dietary supplement (health product) can provide the body with more "materials" to rebuild its "cushion". Gold Shell High Density Chitosan Some researchers believe that glucosamine hydrochloride and glucosamine sulfate have different mechanisms of action. They believe that sulfate, as a part of glucosamine sulfate, is an important element used by the body to synthesize cartilage tissue.